After losing by 24 points to the New England Patriots, the Bills will next play the San Francisco 49ers, only this time they’ll be on the road.

Buffalo was looking pretty good at 2-1, with wins over the Kansas City Chiefs and Cleveland Browns, but then Tom Brady and company came in to town and made a huge statement.

The Bills surrendered 580 total yards of offense and turned it over a whopping six times, including four interceptions by Ryan Fitzpatrick. The former Harvard quarterback was also sacked three times.

Nonetheless, Fitzpatrick was able to move the ball with relative ease as he finished with 350 passing yards and four touchdowns. Scott Chandler had two scores and Donald Jones and Brad Smith caught the other touchdowns.

Obviously it was the defense that was a complete mess for Chain Gailey’s team.

The Bills had held the Patriots to seven points in the first half, but then they came out and got tormented for 45 points, 31 of which came in the fourth quarter alone. It looked like they had simple given up in the closing stages.

That’s incredibly worrying with a daunting trip to San Francisco up on the schedule next.

The 49ers are coming off a rout of the New York Jets and will be feeling good about their chances in all facets of the game. That’s why they’re favored by

The 49ers are coming off a rout of the New York Jets and will be feeling good about their chances in all facets of the game. That’s why they’re favored by double figures on the NFL odds board for this week 5.

Buffalo will need to figure out something and do it fast. Will Fred Jackson or C.J. Spiller get a majority of the carries? Can Fitzpatrick refrain from making poor decisions and poor throws against a hungry 49ers defense?

A lot of questions will have to be answered this weekend, but the initial signs are not looking good for the Bills in Week 5.