After last week’s embarrassing loss to the Seattle Seahawks, the Giants (3-2) will look to rebound at home against the resurgent Buffalo Bills (4-1). With next week’s bye looming and an imposing second half schedule, the Giants must have this game.With Buffalo being extremely vulnerable on the ground, the Giants must establish the run early and often. Here are three keys to the Week 6 match-up.

This Week's Key Player--AP Photo

1. Establish the Run Early To Keep Bills Defense Off-Balance: The Buffalo Bills have played extremely aggressive defense, but have been very beatable on the ground. Opponents have registered 135 yards per game (5.3 average). The Giants will be without Brandon Jacobs again, so expect the Giants to lean heavily on Ahmad Bradshaw. Expect the Bills to stack the box and pressure Eli to throw down field. The Buffalo defense has intercepted 12 passes, the most in the NFL.

2. Stop Fred Jackson: Fred Jackson is the Rodney Dangerfield of running backs–he gets no respect!

Jackson is second among running backs in terms of total yardage (612 yards). Jackson is one of the league’s best dual threats and is the engine that makes the Buffalo offense go. Buffalo has averaged 32.8 points per game and Jackson is the main reason why. The Giants are giving up 122.8 yards per game on the ground, so this will be an interesting match-up to watch.

3. Key Match-Up: NYG D-Line vs. BUF O-Line: The Giants have registered the most sacks in the NFL (18) while the Bills offensive line has only allowed four. Justin Tuck will not play in this game, but Osi has registered four sacks in his first two games while JPP continues to haunt QBs, registering 6.5 sacks. If the Giant defensive line put pressure on Bills’s QB, Ryan Fitzpatrick, they’ll have a successful day.

Look for the Giant wide receivers to put pressure on the Buffalo secondary. The Giants have a big, physical receiver in Hakeem Nicks that will cause issues for the smaller secondary.

Eli was a bit erratic next week, but expect a bounce back performance in a must-win game. 

Las Vegas has the Giants pegged as a three-point favorite which seems about right. I like the Giants to come out on top in this one. I think they’ll have success on the ground and put a ton of pressure on Ryan Fitzpatrick.

Giants 24
Bills 20